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Prof. Dr. med. Patrice M. Ambühl

Stellvertretender Medizinischer Direktor / Departementsleiter Medizinische Institute / Chefarzt Institut für Nephrologie

Facharzt für Allgemeine Innere Medizin
Facharzt für Nephrologie
Institut für Nephrologie im Stadtspital Waid
E-Zuweisung

Kontakt

Stadtspital Zürich Waid
Institut für Nephrologie
Tièchestrasse 99
8037 Zürich
  
Kontaktformular

Kaderfunktionen

Jahr
Funktion
2018 bis heuteLeiter Departement Medizinische Institute, Stellvertretender Medizinischer Direktor
Seit 2007Chefarzt Institut für Nephrologie, Stadtspital Waid
1997-2007Oberarzt am Departement Innere Medizin und der Abteilung für Nephrologie am Universitätsspital Zürich, davon von September 2002 bis Dezember 2003 als interimistischer Abteilungsleiter

Aus- und Weiterbildung

Jahr
Ausbildung / Titel
2008Verleihung der Titular-Professur durch die Medizinische Fakultät der Universität Zürich
2002Habilitation an der Medizinischen Fakultät der Universität Zürich
1995–1997Postdoctoral Fellowship an der University of Texas Southwestern Medical School, Dallas, TX,
1993–1994Ausbildung in Nephrologie, Kantonsspital St. Gallen,
1991–1992Medizinische Universitätsklinik des Inselspitals Bern
1990Ausbildung in Innerer Medizin an der Medizinischen Abteilung Spital Aarberg
1988–1989Postgraduate Ausbildung in Molekularbiologie am Ludwig Institut für Krebsforschung, Bern, und dem Institut für Pathologie der Universität Zürich,
1987Doktorat
1987Dissertation an der Medizinischen Fakultät der Universität Bern
1981–1987Medizinstudium, Universität Bern

Zusatzqualifikationen

Jahr
Ausbildung / Titel / Funktion
Seit 2018Mitglied des Steering Committees des European Renal Transplant and Dialysis Registry
Seit 2013CEO des Swiss Renal Registry and Quality Assessment Program
Seit 2007Mitglied der Schweizerischen Dialysekommission

Forschung

  • Forschungstätigkeit auf dem Gebiet der Nierenkrankheiten und Nierenersatzverfahren

Schwerpunkte:

  • «Erfassung der Lebensqualität und des Krankheitsverlaufes bei Langzeit-Hämodialysepatienten in Abhängigkeit von kardiovaskulären Risikofaktoren, Ernährungszustand und Dialysebehandlung» (multizentrische Kohortenstudie)
  • «Metabolische Azidose und deren Auswirkungen auf Mineralstoffwechsel und körperliche Leistungsfähigkeit bei Patienten nach Nierentransplantation» (Projekt des Schweizerischen Nationalfonds in Zusammenarbeit mit der Universität und ETH Zürich)

Publikationen

Kitty J. Jager, Anneke Kramer, Nicholas C. Chesnaye , Cécile Couchoud , J. Emilio Saáchez-Alvarez, Liliana Garneata, Freéderic Collart, Marc H. Hemmelder, Patrice Ambühl, Julia Kerschbaum, Camille Legeai, María Dolores del Pino y Pino1, Gabriel Mircescu, Lionel Mazzoleni, Tiny Hoekstra, Rebecca Winzeler, Gert Mayer, Vianda S. Stel, Christoph Wanner, Carmine Zoccali and Ziad A. Massy. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney International (2020) 98, 1540–1548.

Markus Ketteler & Patrice Ambühl. Where are we now? Emerging opportunities and challenges in the management of secondary hyperparathyroidism in patients with non-dialysis chronic kidney disease. Journal of Nephrology. https://doi.org/10.1007/s40620-021-01082-2.

Ambühl PM. Nierensteine. Ther Umsch. 2021 Jun;78(5):205. Doi.

Giliane Nanchen, Kevin Schutzbach, Samuel Rotman, Rebecca Winzeler, Patrice Ambühl, Matthieu Halfon, MennoPruijm. Incidence of glomerulonephritis in the western part of Switzerland over the last decade. Swiss Med Wkly. 2020 Oct 6;150:w20353. doi: 10.4414/smw.2020.20353.

Alder H, Ambühl PM. Managing Diabetic Kidney Disease. Ther Umsch. 2020 Sep;77(7):333-338. doi.

Boenink R, Stel VS, Waldum-Grevbo BE, Collart F, Kerschbaum J, Heaf JG, de Meester J, Finne P, García-Marcos SA, Evans M, Ambühl PM, Arici M, Ayav C, Steenkamp R, Cases A, Traynor JP, Palsson R, Zoccali C, Massy ZA, Jager KJ, Kramer A. Data from the ERA-EDTA Registry were examined for trends in excess mortality in European adults on kidney replacement therapy. Kidney Int. 2020 Oct;98(4):999-1008. doi: 10.1016/j.kint.2020.05.039. Epub 2020 Jun 20. PMID: 32569654.

Ernst R, Fischer K, de Godoi Rezende Costa Molino C, Orav EJ, Theiler R, Meyer U, Fischler M, Gagesch M, Ambühl PM, Freystätter G, Egli A, Bischoff-Ferrari HA. Polypharmacy and Kidney Function in Community-Dwelling Adults Age 60 Years and Older: A Prospective Observational Study. J Am Med Dir Assoc. 2020 Feb;21(2):254-259.e1. doi: 10.1016/j.jamda.2019.07.007. Epub 2019 Sep 6.

Harald Seeger, Andrea Kaelin, Pietro M Ferraro, Damian Weber, Philippe Jaeger, Patrice Ambühl, William G Robertson, Robert Unwin, Carsten A Wagner, Nilufar Mohebbi. Changes in urinary risk profile after short-term low sodium and low calcium diet in recurrent Swiss kidney stone formers. BMC Nephrol. 2017 Dec 4;18(1):349. doi: 10.1186/s12882-017-0755-7.

Anneke Kramer, Maria Pippias, Marlies Noordzij, Vianda S. Stel, Nikolaos Afentakis, Patrice M. Ambühl et al. The European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2015: a summary. Clinical Kidney Journal, 2018, 1–15

Ambühl PM. Aktuelle Erkenntnisse zur Schweizer Dialysepopulation. Hausarzt Praxis. 2017, 3: 22-26.

Curti A, Schwarz A, Trachsler J, Tomonaga Y, Ambühl PM. Therapeutic Efficacy and Cost Effec-tiveness of High Cut-Off Dialyzers Compared to Conventional Dialysis in Patients with Cast Ne-phropathy. PLoS One. 2016 Jul 28;11(7):e0159942. doi: 10.1371/journal.pone.0159942

Kramer A, Pippias M, Stel VS, Bonthuis M, Abad Diez JM, Afentakis N, Alonso de la Torre R, Ambühl P et al. Renal replacement therapy in Europe: a summary of the 2013 ERA-EDTA Registry Annual Report with a focus on diabetes mellitus. Clin Kidney J. 2016 Jun;9(3):457-69. doi: 10.1093/ckj/sfv151.

Risch M, Risch L, Purde M-T, Renz H, Ambühl PM, Szucs T, Tomonaga Y. Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study. Scand J Clin Lab Invest 2016; 76(5):379-85.

Flury S, Trachsler J, Schwarz A, Ambühl PM. Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis. BMC Nephrol 2015 Oct 27; 16:174.

Sunil Bhandari, Philip A. Kalra, Jatin Kothari, Patrice Ambühl, Jeppe H. Christensen, Ashot M. Essaian, Lars L. Thomsen, Iain C. Macdougall and Daniel W. Coyne. A randomized, open-label trial of iron isomaltoside 1000 (Monofer®) compared with iron sucrose (Venofer®) as maintenance therapy in haemodialysis patients. Nephrol Dial Transplant 2015: 1–13.

Tomonaga Y, Risch L, Szucs TD, Ambühl PM. The prevalence of chronic kidney disease in a pri-mary care setting: a Swiss cross-sectional study. PLoS One. 2013 Jul 3;8(7).

Eisenberger U, Wüthrich RP, Bock A, Ambühl P, Steiger J, Intondi A, Kuranoff S, Maier T, Green D, DiCarlo L, Feutren G, De Geest S. Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants. Transplantation. 2013 Aug 15;96(3):245-50.

Ambühl PM. Nephrolithiasis im Alter. Der informierte Arzt. 2016 (1): 20-23.

Yakupoglu HY, Budak K, Ambühl PM. Praxis (Bern 1994). Urolithiasis. 2013 Aug 7;102(16):961-9. doi: 10.1024/1661-8157/a001398.

Yakupoglu HY, Budak K, Ambühl PM. Praxis (Bern 1994). Urolithiasis. 2013 Jun 19;102(13):767-74. doi: 10.1024/1661-8157/a001358.

Starke A, Corsenca A, Kohler T, Knubben J, Kraenzlin M, Uebelhart D, Wüthrich RP, von Rechen-berg B, Müller R, Ambühl PM. Correction of Metabolic Acidosis with Potassium Citrate in Renal Transplant Patients and its Effect on Bone Quality. Clin J Am Soc Nephrol. 2012 Jul 5. [Epub ahead of print]

Rhyn Lehmann P, Ambühl M, Corleto D, Klaghofer R, Ambühl PM. Epidemiologic trends in chronic renal replacement therapy over forty years: A Swiss dialysis experience. BMC Nephrol. 2012 Jul 2;13:52.

Tomonaga Y, Szucs T, Ambühl P, Nock S, Risch M, Risch L. Insights on urinary NGAL obtained in a primary care setting. Clin Chim Acta. 2012 Apr 11;413(7-8):733-9. Epub 2012 Jan 9.

Ambühl PM. Protein intake in renal and hepatic disease. Int J Vitam Nutr Res. 2011, 81(2-3):162-72.

Goetzmann L, Lieberherr M, Krombholz L, Ambühl PM, Boehler A, Noll G, Muellhaupt B, Wagner R, Buddeberg C, Klaghofer R. Subjektives Erleben nach einer Organtransplantation –eine qualitati-ve Studie mit 120 Herz-, Lungen-, Leber- und Nierenempfängern. Z Psychosom Med Psychother. 2010;56(3):268-82.

Mertz KD, Proske D, Kettelhack N, Kegel C, Keusch G, Schwarz A, Ambühl PM, Pfaltz M, Kempf W. Basal cell carcinoma in a series of renal transplant recipients: epidemiology and clinicopatholo-gic features. Int J Dermatol. 2010 Apr;49(4):385-9.

Etter C, Straub Y, Hersberger M, Räz HR, Kistler T, Kiss D, Wüthrich RP, Gloor HJ, Aerne D, Wahl P, Klaghofer R, Ambühl PM. Pregnancy-associated plasma protein-A is an independent short-time predictor of mortality in patients on maintenance haemodialysis. Eur Heart J. 2010 Feb;31(3):354-9. Epub 2009 Oct 21.

Abedini S, Holme I, März W, Weihrauch G, Fellström B, Jardine A, Cole E, Maes B, Neumayer HH, Grønhagen-Riska C, Ambühl PM, Holdaas H; on behalf of the ALERT study group. Inflammation in renal transplantation. Clin J Am Soc Nephrol. 2009 Jul;4(7):1246-1254.

Valli PV, Puga Yung G, Fehr T, Schulz-Huotari C, Kaup N, Güngör T, Ambühl PM, Weber M, Schanz U, Seebach JD, Stüssi G. Changes of circulating antibody levels induced by ABO antibody adsorption for ABO-incompatible kidney transplantation. Am J Transplant. 2009 May;9(5):1072-80.

Goetzmann L, Ruegg L, Stamm M, Ambühl PM, Boehler A, Halter J, Muellhaupt B, Noll G, Schanz U, Wagner-Huber R, Spindler A, Buddeberg C, Klaghofer R. Psychosocial profiles after transplan-tation: a 24-month follow-up of heart, lung, liver, kidney and allogeneic bone-marrow patients. Transplantation. 2008 Sep 15;86(5):662-8.

Goetzmann L, Sarac N, Ambühl PM, Boehler A, Irani S, Muellhaupt B, Noll G, Schleuniger M, Schwegler K, Buddeberg C, Klaghofer R. Psychological response and quality of life after transplantation: a comparison between heart, lung, liver and kidney recipients. Swiss Med Wkly. 2008 Aug 23;138(33-34):477-83.

Bunnapradist S, Ambühl PM. Impact of gastrointestinal-related side effects on mycophenolate mo-fetil dosing and potential therapeutic strategies. Clin Transplant. 2008.

Yakupoglu HY, Corsenca A, Wahl P, Wüthrich RP, Ambühl PM. Posttransplant acidosis and associated disorders of mineral metabolism in patients with a renal graft. Transplantation 2007 Nov 15;84(9):1151-7.

Schmid S, Opravil M, Moddel M, Huber M, Pfammatter R, Keusch G, Ambühl PM, Wüthrich RP, Moch H, Varga Z. Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies. Virchows Arch. 2007 Jun;450(6):665-70.

Calanca LN, Fehr T, Jochum W, Fischer-Vetter J, Mullhaupt B, Wüthrich RP, Ambühl PM. Combi-nation therapy with ribavirin and amantadine in renal transplant patients with chronic hepatitis C vi-us infection is not superior to ribavirin alone. J Clin Virol. 2007 May;39(1):54-8.

Ambühl PM, Tissot AC, Fulurija A, Maurer P, Nussberger J, Sabat R, Nief V, Schellekens C, Slad-ko K, Roubicek K, Pfister T, Rettenbacher M, Volk HD, Wagner F, Muller P, Jennings GT, Bach-mann MF. A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity. J Hypertens. 2007 Jan;25(1):63-72.

Schiesser D, Binet I, Tsinalis D, Dickenmann M, Keusch G, Schmidli M, Ambühl PM, Lüthi L, Wüthrich RP. Weekly low-dose treatment with intravenous iron sucrose maintains iron status and decreases epoetin requirement in iron-replete haemodialysis patients. Nephrol Dial Transplant 2006 Oct;21(10):2841-5.

Mulgaonkar S, Walker R, Arns W, Ambühl PM, Schiavelli R. Patient-reported gastrointestinal symp-tom burden and health-related quality of life following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium. Transplantation 2006 May 81(9):1290-7.

Dyntar D, Sergeev P, Klisic J, Ambühl PM, Schaub MC, Donath MY. High glucose alters cardio-myocyte contacts and inhibits myofibrillar formation. J Clin Endocrinol Metab. 2006 Ma-y;91(5):1961-7.

Cao C, Hellermann JP, Weber M, Ambühl PM. Time trends in the epidemiology of renal transplant patients with type 1 diabetes mellitus over the last four decades. Nephrol Dial Transplant 2006 Mar;21(3):770-775.

Ambühl PM. Pathophysiologie und Diagnostik renal tubulärer Azidosen. Therapeutische Umschau 2006, 63(9):601-608.

Ambühl PM. Proteinurie: "To screen or not to screen?" Schweiz Med Forum (Schlaglichter 2005) 2006;6:22-23.

Holdaas H, Fellstrom B, Cole E, Nyberg G, Olsson AG, Pedersen TR, Madsen S, Gronhagen-Riska C, Neumayer HH, Maes B, Ambühl PM, Hartmann A, Staffler B, Jardine AG. Long-term Cardiac Outcomes in Renal Transplant Recipients Receiving Fluvastatin: The ALERT Extension Study. Am J Transplant 2005 Dec;5(12):2929-36.

Klisic J, Nief V, Reyes L, Ambühl PM. Acute and chronic regulation of the renal Na+/H+ exchanger NHE3 in rats with STZ induced diabetes mellitus. Nephron 2005 Oct 19;102(2):27-35.

Jardine AG, Fellstrom B, Logan JO, Cole E, Nyberg G, Gronhagen-Riska C, Madsen S, Neumayer HH, Maes B, Ambühl PM, Olsson AG, Pedersen, Terje, Pedersen T, Holdaas H. Cardiovascular risk and renal transplantation: post hoc analyses of the Assessment of Lescol in Renal Transplanta-tion (ALERT) Study. Am J Kidney Dis. 2005 Sep;46(3):529-36.

Fellstrom B, Holdaas H, Jardine AG, Nyberg G, Gronhagen-Riska C, Madsen S, Neumayer HH, Cole E, Maes B, Ambühl PM, Olsson AG, Staffler B, Pedersen TR. Risk Factors for Reaching Renal Endpoints in the Assessment of Lescol in Renal Transplantation (ALERT) Trial. Transplanta-tion. 2005 Jan 27;79(2):205-212.

Kleinmann L, Faull R, Walker R, Ramesh Prasad GV, Ambühl PM, Bahner U. Gastrointestinal-specific patient-reported outcome instruments differentiate between renal transplant patients with or without GI complications. Transplant Proc 2005; 37:846-849.

Ambühl PM. Surviving the pills and the doctor! Nephrol Dial Transplant. 2005 Jun;20(6):1267-8.

Nigg L, Schanz U, Ambühl PM, Fehr J, Bachli EB. Prolonged course of pure red cell aplasia after erythropoietin therapy. Eur J Haematol. 2004 Nov;73(5):376-9.

Fellstrom B, Holdaas H, Jardine AG, Holme I, Nyberg G, Fauchald P, Gronhagen-Riska C, Madsen S, Neumayer HH, Cole E, Maes B, Ambühl PM, Olsson AG, Hartmann A, Logan JO, Pedersen TR; Assessment of Lescol in Renal Transplantation Study Investigators. Effect of fluvastatin on renal end points in the Assessment of Lescol in Renal Transplant (ALERT) trial. Kidney Int 2004; 66:1549-55.

Miozzari M, Ambühl PM. Steroid withdrawal after long-term medication for immunosuppressive therapy in renal transplant patients: adrenal response and clinical implications. Nephrol Dial Trans-plant 2004; 19:2615-21.

Lehmann R, Weber M, Berthold P, Zullig R, Pfammatter T, Moritz W, Madler K, Donath M, Ambühl PM, Demartines N, Clavien And PA, Andreia Spinas G. Successful Simultaneous Islet-Kidney Transplantation using a Steroid-free Immunosuppression: Two-Year Follow-up. Am J Transplant. 2004; 4:1117-23.

Jardine AG, Holdaas H, Fellstrom B, Cole E, Nyberg G, Gronhagen-Riska C, Madsen S, Neuma-yer HH, Maes B, Ambühl PM, Olsson AG, Holme I, Fauchald P, Gimpelwicz C, Pedersen TR; ALERT Study Investigators. Fluvastatin prevents cardiac death and myocardial infarction in renal transplant recipients: post-hoc subgroup analyses of the ALERT Study. Am J Transplant. 2004; 4:988-95.

Nigg L, Schanz U, Ambühl PM, Fehr J, Bächli EB. Prolonged course of pure red cell aplasia after erythropoietin therapy. Eur J Haematol 2004; 3:376-9.

Fehr T, Ambühl PM. Chronic hepatitis virus infections in patients on renal replacement therapy. Nephrol Dial Transplant. 2004; 19:1049-53.

Klisic J, Zhang J, Nief V, Reyes L, Moe OW, Ambühl PM. Albumin regulates the Na+/H+ exchan-ger 3 (NHE3) in OKP cells. J Am Soc Nephrol. 2003;14:3008-16.

Fehr T, Riehle HM, Nigg L, Gruter E, Ammann P, Renner EL, Ambühl PM. Evaluation of hepatitis B and hepatitis C virus-infected renal allograft recipients with liver biopsy and noninvasive parame-ters. Am J Kidney Dis 2003;42:193-201.

Holdaas H, Fellstrom B, Jardine AG, Holme I, Nyberg G, Fauchald P, Gronhagen-Riska C, Madsen S, Neumayer HH, Cole E, Maes B, Ambühl PM, Olsson AG, Hartmann A, Solbu DO, Pedersen TR. Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomi-sed, placebo-controlled trial. Lancet 2003; (9374):2024-31.

Mullhaupt B, Kullak-Ublick GA, Ambühl PM, Stocker R, Renner EL. Successful use of the Molecular Adsorbent Recirculating System (MARS) in a patient with primary biliary cirrhosis (PBC) and treatment refractory pruritus. Hepatol Res 2003:442-446.

Hansen T, Ambühl PM, Michel BA, Kyburz D. Chondrocalcinosis and osteoporosis in a patient with renal tubular disorder. EXCLI Journal 2003;2:1-5.

Mullhaupt B, Kullak-Ublick G, Ambühl PM, Maggiorini M, Stocker R, Kadry Z, Clavien P, Renner E. First clinical experience with Molecular Adsorbent Recirculating System (MARS) in six patients with severe acute on chronic liver failure. Liver 2002; 22 Suppl 2:59-62.

Weber M, Dindo D, Demartines N, Ambühl PM, Clavien PA. Kidney transplantation from donors without a heartbeat. N Engl J Med 2002; 347:248-55.

Besse-Eschmann V, Klisic J, Nief V, Le Hir M, Kaissling B, Ambühl PM. Regulation of the Proximal Tubular Sodium/Proton Exchanger NHE3 in Rats with Puromycin Aminonucleoside (PAN)-Induced Nephrotic Syndrome. J Am Soc Nephrol 2002;13:2199-206.

Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambühl PM. Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol 2002; 283:F532-9.

Ambühl PM. Mit dem Ohr in die Niere gehorcht. Schweiz Med Forum 2002;2:820.

Hailemariam S, Walder M, Burger H-R, Cathomas G, Mihatsch M, Binswanger U, Ambühl PM. Renal pathology and premortem clinical presentation of Caucasian patients with AIDS: an autopsy study from the era prior to antiretroviral therapy. Swiss Medical Weekly 2001; 131:412-417.

Lukaschek J, Hofmann J, Aerne D, Ambühl PM, Kistler T, Knoflach A, Pei P, Binswanger U. Neoral drug monitoring in stable kidney allotransplant recipients: C(0) versus C(2). Transplant Proc 2001;33:3104-3105.

Kistler T, Ambühl PM. Renal safety of combined cyclooxygenase 2 (COX-2) inhibitor and angioten-sin II (Ang II) receptor blocker administration in mild volume depletion. Swiss Medical Weekly 2001; 131:193-198.

Ambühl PM. Klinik und Therapie des akuten Nierenversagens. Schweiz Med Forum 2001:227-231.

Ambühl PM. Ursachen und Pathogenese des akuten Nierenversagens. Schweiz Med Forum 2001:232-236.

Ambühl PM. Fehlender Endothelin-Rezeptor in der Niere verursacht "Salz-Hypertonie". Schweiz Med Forum 2001;1:281.

Leumann E, Goetschel P, Neuhaus TJ, Ambühl PM, Candinas D. Nierentransplantation und Le-bendspende – aus der Not eine Tugend. Schweiz Med Wochenschrift 2000; 130:1581-1589.

Wüthrich RP, Cicvara S, Ambühl PM, Binswanger U. Randomized trial of conversion from myco-phenolate to azathioprine six months after renal allograft transplantation. Nephrol Dial Transplant 2000, 15:1228-1231.

Ambühl PM, Binswanger U, Renner E. Epidemiologie der chronischen Hepatitis B und C bei Dialy-sepatienten in der Schweiz. Schweiz Med Wochenschrift 2000, 130:341-348.

Weber M, Demartines N, Ambühl PM, Kadry Z, Clavien PA. Kidney transplantation in Switzerland. Clin Transpl 2000; 398-399.

Acar YO, Bauerfeind P, Ambühl PM, Fried M, Hauri D. Mechanisms of acid secretion in gastro pouch. Urology 1999, 54:553-556.

Ambühl PM, Müller V, Binswanger U. Transient proteinuria after infusion of a gelatin plasma volu-me expander. Clinical Nephrology 1999, 52:399-400.

Ambühl PM, Meier D, Wolf B, Dydak U, Bösiger P, Binswanger U. Metabolic aspects of phosphate replacement therapy for hypophosphatemia after renal transplantation: impact on muscular phos-phate content, mineral metabolism and acid/base homeostasis. Am Journal Kidney Dis 1999, 34:875-883.

Wüthrich RP, Weinreich T, Ambühl PM, Schwarzkopf A-K, Candinas D, Binswanger U. Reduced kidney transplant rejection rate and pharmacoeconomic advantage of mycophenolate mofetil. Ne-phrol Dial Transplant 1999, 2:394-399.

Ambühl PM, Yang X, Peng Y, Preisig PA, Moe OW, Alpern RJ. Glucocorticoids enhance acid acti-vation of NHE3. J Clin Invest 1999, 103:429-435.

Ambühl PM, Müller V, Binswanger U. Transient proteinuria after infusion of a gelatin plasma volume expander. Clinical Nephrology 1999, 52:399-400.

Ambühl PM, Alpern RJ. Role of glucocorticoids in acidosis. Am Journal Kidney Dis 1999; 34 (5):960-965.

Ambühl PM, Zajicek HK, Wang H, Puttaparthi K, Levi M. Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat. Kidney Intl 1998, 53:1288-1298.

Ambühl PM, Amemiya M, Preisig PA, Moe OW, Alpern RJ. Chronic hyperosmolality increases NHE3 activity in OKP cells. J Clin Invest 1998, 101: 170-177.

Ambühl PM, Ballmer PE, Krähenbühl S, Krapf R. Quantification and predictors of plasma volume expansion from mannitol treatment. Intensive Care Med 1997, 23: 1159-1164.

Ambühl PM, Wüthrich RP, Korte W, Schmid L, Krapf R. Plasma hypercoagulability in haemodialy-sis patients: impact of dialysis and anticoagulation. Nephrol Dial Transplant 1997, 12: 2355-2364.

Laghmani K, Borensztein P, Ambühl PM, Froissart M, Bichara M, Moe OW, Alpern RJ, Paillard M. Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA. J Clin Invest 1996, 99:24-30.

Ambühl PM, Amemija M, Lötscher M, Kaissling B, Moe O, Preisig P, Alpern RJ: Chronic metabolic acidosis increases NHE-3 protein abundance in rat kidney. Am J Physiol 1996, 271:F917-F925.

Ambühl PM, Schweizer W, Laeng H, Ballmer PE. Huge cystic lipogranuloma mimicking a malig-nant tumor. Digestive Surgery 1995; 12:195-198.

Ambühl PM, Ballmer PE, Krähenbühl S. Fulminante Hepatitis: Pathogenese, Klinik und Management. Schweiz Med Wochenschr 1994; 124: 368-380.

Schäfer R, Iyer J, Iten E, Nirkko AC, Ambühl PM. Identification and functional analysis of tumor suppressor genes by transfection. Current Communications in Molecular Biology (Recessive On-cogenes and Tumor Suppression), Cold Spring Harbor, New York 1990: 169-177.

Ambühl PM. Die Bedeutung von Suppressorgenen im molekularen Konzept der Krebsentstehung. Berichte der Österreichischen Gesellschaft für Klinische Chemie 1989, 12: 125-128.

Schäfer R, Nirkko AC, Ambühl PM, Grzeschik KH, Schwarte Waldhoff I. Evidence for human DNA-mediated transfer of the suppressed phenotype into malignant Chinese hamster cells. On-cogene 1991; 6: 2221-2228.

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